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Magic™ Membrane Protein Human RYK (Receptor like tyrosine kinase) Expressed in CHO for Antibody Discovery, Partial (46-224aa) (CAT#: MPX0160K)

Datasheet
This product is a 46.7 kDa Human RYK membrane protein expressed in CHO. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • RYK
  • Protein Length
  • Partial (46-224aa)
  • Protein Class
  • Transferase
  • Molecular Weight
  • 46.7 kDa
  • TMD
  • 1
  • Sequence
  • AAPAP
    RPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSL
    LVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTL
    SVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEE
    VKTSALDKNTSRTIYDPVHAAPTT

Product Description

  • Expression Systems
  • CHO
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 500 μg/mL in PBS.
  • Endotoxin
  • <1.0 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • RYK
  • Full Name
  • Receptor like tyrosine kinase
  • Introduction
  • The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Alternative Names
  • RYK; JTK5; RYK1; JTK5A; D3S3195; tyrosine-protein kinase RYK; JTK5A protein tyrosine kinase; hydroxyaryl-protein kinase; Receptor like tyrosine kinase

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