Magic™ Membrane Protein Human CCR10 (C-C motif chemokine receptor 10) for Antibody Discovery (CAT#: MP1330J)

Datasheet

This product is a 38 kDa Human CCR10 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

Host Species
Human

Target Protein
CCR10

Protein Length
Full-length

Protein Class
GPCR

Molecular Weight
38 kDa

Sequence
MGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNG LVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLY SASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFS QDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGP ERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLAL ARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSW DN

Product Description

Expression Systems
E.coli

Tag
N-His or Tag-Free

Reconstitution
Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration).

Purity
>85% as determined by SDS-PAGE

Buffer
Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Target

Target Protein
CCR10

Full Name
C-C motif chemokine receptor 10

Introduction
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.

Alternative Names
C C chemokine receptor type 10; C-C chemokine receptor type 10; C-C CKR-10; CC chemokine receptor 10; CC CKR 10; CC-CKR-10; CCR-10; CCR10; CCR10_HUMAN; Chemokine (C C motif) receptor 10; G protein coupled receptor 2; G-protein coupled receptor 2; GPR2

Gene ID
2826

UniProt ID
P46092

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